Fowl pox vaccine is produced by cloning the virus and propagating it via tissue culture. This is the first tissue cultured adapted technology developed in Malaysia. The special features of this new clone are that it can grow well in tissue cultures, give a high titre ; produces homogenous and high quality vaccine which can be prepared in the freeze-dried form. This technique of preparation reduces operational costs and shortens production time per dose as compared to those using embryonated eggs. This vaccine is also more stable, has a long shelf-life and can be used for all types of chickens.