An isolated peptide for use in detecting early cancer progression comprising any one or combination of peptide sequence of seq no. 1, seq no. 2, seq no. 3, seq no. 4, seq no. 5, seq no. 6, seq no. 7, seq no. 8, seq no. 9. Seq no. 1 0, seq no. 1 1, seq no. 12, seq no. 13, seq no. 14 and seq no. 15.