Osteoarthritis is a degenerative joint disease affecting the elderly population worldwide. The condition severely reduces mobility and quality of life among the elderly. Effective treatment for osteoarthritis is not available at this moment since most of the drugs only target the symptoms of osteoarthritis. Tocotrienol can target the self-propagating destruction of cartilage in osteoarthritis induced by inflammation. We have established the composition and dosage of tocotrienol effective in halting joint destruction in animals. The efficacy of tocotrienol in preventing and treating osteoarthritis still needs to be validated in a human study.