The present invention relates generally to a method for the isolation of malabaricones AC and giganteone A from the bark of Myristica cinnamomea King. Accordingly, the method includes: a) extracting the dried powdered bark of Myristica cinnamomea with hexane followed by acetone at room temperature, with affording extracts, b) re-extracting the obtained acetone extract with ethyl acetate (EtOAc) at room temperature to the desired yield extract; c) chromatographing the ethyl acetate (EtOAc) extract over a silica gel column eluting with dichloromethane (CH2Cl2) gradually enriched with ethyl acetate (EtOAc); wherein malabaricones A-C and giganteone A were obtained by designated fractions of CH2Cl2 : EtOAc.