The leucite glass ceramics is produced using Malaysian silica sand as the SiO2 raw material. Sintering of SiO2-Al2O3-K2O glass powder at 850°C for duration of 1 hour contributed to the crystallization of leucite. The leucite glass-ceramics has a flexural strength comparable with commercial product. The absence of apatite layer on the surface indicated that it is inert bioactive material. The leucite glass-ceramics is also ranked non-cytotoxic in terms of in-vitro cellular response to human cell lines under the prevailing test conditions.