A vaccine against mannhemiosis of sheep and goats. It which is, developed by using recombinant technology. This technology is used to control a respiratory disease of sheep and goats, that usually causes up to 30% mortality during rainy season. It is produced by using sophisticated recombinant technology which is, proven to provide protection against bacterium infection. The vaccine is administered intranasally into sheep and goats. The advantages are; it is effective if used according to the suggested protocol; it can reduce mortality to more than 90% and easy to use.